Helen Mirren portrays Patricia Highsmith in the new film A Talent for Murder, under the direction of Anton Corbijn. Critics have described her performance as biting and abrasive. Mirren has called Highsmith the toughest real-life individual she has ever played, noting her abrasive nature.

Both Mirren and Brosnan defended the actor Tom Hardy amid reports of conflict during the filming of MobLand. Mirren discussed the role at TIFF.